Scientific Evidence

Welcome to our evidence library! Ensuring that you can access the evidence supporting our product and the statements made about it, is a priority for us. Below, you’ll find a collection of studies that informed the development of our app and its marketing messages. If you have any questions or concerns, please don’t hesitate to reach out to us at (info@silentcloud.com).

SilentCloud is a medical software tool that offers proven therapies to reduce the tinnitus burden.
Clinical benefit of Cognitive Behavioral Therapy (CBT)
  1. Weise, C., Kleinstäuber, M., & Andersson, G. (2016). Internet-delivered cognitive-behavior therapy for tinnitus: a randomized controlled trial. Psychosomatic Medicine, 78(4), 501–510. https://doi.org/10.1097/PSY.0000000000000310
  2. Hesser, H., Gustafsson, T., Lundén, C., Henrikson, O., Fattahi, K., Johnsson, E., Westin, V. Z., Carlbring, P., Mäki-Torkko, E., Kaldo, V., & Andersson, G. (2012). A randomized controlled trial of Internet-delivered cognitive behavior therapy and acceptance and commitment therapy in the treatment of tinnitus. Journal of Consulting and Clinical Psychology, 80(4), 649–661. https://doi.org/10.1037/a0027021
  3. Jasper, K., Weise, C., Conrad, I., Andersson, G., Hiller, W., & Kleinstäuber, M. (2014). Internet-based guided self-help versus group cognitive behavioral therapy for chronic tinnitus: a randomized controlled trial. Psychotherapy and Psychosomatics, 83(4), 234–246.https://doi.org/10.1159/000360705
  4. Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham Jr, E. R., Archer, S. M., Blakley, B. W., Carter, J. M., Granieri, E. C., Henry, J. A., Hollingsworth, D., Khan, F. A., Mitchell, S., Monfared, A., Newman, C. W., Omole, F. S., Philips, C. D., Robinson, S. K., . . . Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology–Head and Neck Surgery, 151(2_suppl), S1–S40. https://doi.org/10.1177/0194599814545325
  5. Cima, R. F. F., Mazurek, B., Haider, H., Kikidis, D., Lapira, A., Noreña, A., & Hoare, D. J. (2019). A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO, 67(1), 10–42. https://doi.org/10.1007/s00106-019-0633-7
Clinical benefit of sound therapy
  1. Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham Jr, E. R., Archer, S. M., Blakley, B. W., Carter, J. M., Granieri, E. C., Henry, J. A., Hollingsworth, D., Khan, F. A., Mitchell, S., Monfared, A., Newman, C. W., Omole, F. S., Philips, C. D., Robinson, S. K., . . . Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology–Head and Neck Surgery, 151(2_suppl), S1–S40. https://doi.org/10.1177/0194599814545325
  2. Cima, R. F. F., Maes, I. H., Joore, M. A., Scheyen, D. J., El Refaie, A., Baguley, D. M., Anteunis, L. J., van Breukelen, G. J., & Vlaeyen, J. W. (2012). Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial. The Lancet, 379(9830), 1951–1959. https://doi.org/10.1016/S0140-6736(12)60469-3
  3. Theodoroff, S. M., McMillan, G. P., Zaugg, T. L., Cheslock, M., Roberts, C., & Henry, J. A. (2017). Randomized controlled trial of a novel device for tinnitus sound therapy during sleep. American Journal of Audiology, 26(4), 543–554. https://doi.org/10.1044/2017_AJA-17-0022
  4. Theodoroff, S. M., McMillan, G. P., Schmidt, C. J., Dann, S. M., Hauptmann, C., Goodworth, M. C., Leibowitz, R. Q., Random, C., & Henry, J. A. (2022). Randomised controlled trial of interventions for bothersome tinnitus: DesyncraTM versus cognitive behavioural therapy. International Journal of Audiology, 61(12), 1035–1044. https://doi.org/10.1080/14992027.2021.2004325
SilentCloud offers recommended therapies
  1. Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham Jr, E. R., Archer, S. M., Blakley, B. W., Carter, J. M., Granieri, E. C., Henry, J. A., Hollingsworth, D., Khan, F. A., Mitchell, S., Monfared, A., Newman, C. W., Omole, F. S., Philips, C. D., Robinson, S. K., . . . Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology–Head and Neck Surgery, 151(2_suppl), S1–S40. https://doi.org/10.1177/0194599814545325
  2. Cima, R. F. F., Mazurek, B., Haider, H., Kikidis, D., Lapira, A., Noreña, A., & Hoare, D. J. (2019). A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO, 67(1), 10–42. https://doi.org/10.1007/s00106-019-0633-7
Benefit of Cognitive Behavioral Therapy / education and counseling (our CBT is based on validated protocols, worked out with experts in the field)
  1. Weise, C., Kleinstäuber, M., & Andersson, G. (2016). Internet-delivered cognitive-behavior therapy for tinnitus: a randomized controlled trial. Psychosomatic Medicine, 78(4), 501–510. https://doi.org/10.1097/PSY.0000000000000310
  2. Hesser, H., Gustafsson, T., Lundén, C., Henrikson, O., Fattahi, K., Johnsson, E., Westin, V. Z., Carlbring, P., Mäki-Torkko, E., Kaldo, V., & Andersson, G. (2012). A randomized controlled trial of Internet-delivered cognitive behavior therapy and acceptance and commitment therapy in the treatment of tinnitus. Journal of Consulting and Clinical Psychology, 80(4), 649–661. https://doi.org/10.1037/a0027021
  3. Jasper, K., Weise, C., Conrad, I., Andersson, G., Hiller, W., & Kleinstäuber, M. (2014). Internet-based guided self-help versus group cognitive behavioral therapy for chronic tinnitus: a randomized controlled trial. Psychotherapy and Psychosomatics, 83(4), 234–246. https://doi.org/10.1159/000360705
  4. Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham Jr, E. R., Archer, S. M., Blakley, B. W., Carter, J. M., Granieri, E. C., Henry, J. A., Hollingsworth, D., Khan, F. A., Mitchell, S., Monfared, A., Newman, C. W., Omole, F. S., Philips, C. D., Robinson, S. K., . . . Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology–Head and Neck Surgery, 151(2_suppl), S1–S40. https://doi.org/10.1177/0194599814545325
  5. Cima, R. F. F., Mazurek, B., Haider, H., Kikidis, D., Lapira, A., Noreña, A., & Hoare, D. J. (2019). A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO, 67(1), 10–42. https://doi.org/10.1007/s00106-019-0633-7
  6. Kaldo, V., Haak, T., Buhrman, M., Alfonsson, S., Larsen, H. C., & Andersson, G. (2013). Internet-Based Cognitive Behaviour Therapy for Tinnitus Patients Delivered in a Regular Clinical Setting: Outcome and Analysis of Treatment Dropout. Cognitive Behaviour Therapy, 42(2), 146–158. https://doi.org/10.1080/16506073.2013.769622
  7. Kröner-Herwig, B., Jäger, B., & Goebel, G. (2010). Tinnitus: Kognitiv-verhaltenstherapeutisches Behandlungsmanual. Mit Online-Materialien. Beltz.
Benefit of sound therapy (general)
  1. Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham Jr, E. R., Archer, S. M., Blakley, B. W., Carter, J. M., Granieri, E. C., Henry, J. A., Hollingsworth, D., Khan, F. A., Mitchell, S., Monfared, A., Newman, C. W., Omole, F. S., Philips, C. D., Robinson, S. K., . . . Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology–Head and Neck Surgery, 151(2_suppl), S1–S40. https://doi.org/10.1177/0194599814545325
  2. Cima, R. F. F., Maes, I. H., Joore, M. A., Scheyen, D. J., El Refaie, A., Baguley, D. M., Anteunis, L. J., van Breukelen, G. J., & Vlaeyen, J. W. (2012). Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial. The Lancet, 379(9830), 1951–1959. https://doi.org/10.1016/S0140-6736(12)60469-3
  3. Theodoroff, S. M., McMillan, G. P., Zaugg, T. L., Cheslock, M., Roberts, C., & Henry, J. A. (2017). Randomized controlled trial of a novel device for tinnitus sound therapy during sleep. American Journal of Audiology, 26(4), 543–554. https://doi.org/10.1044/2017_AJA-17-0022
  4. Theodoroff, S. M., McMillan, G. P., Schmidt, C. J., Dann, S. M., Hauptmann, C., Goodworth, M. C., Leibowitz, R. Q., Random, C., & Henry, J. A. (2022). Randomised controlled trial of interventions for bothersome tinnitus: DesyncraTM versus cognitive behavioural therapy. International Journal of Audiology, 61(12), 1035–1044. https://doi.org/10.1080/14992027.2021.2004325
  5. Henry, J. A., Schechter, M. A., Zaugg, T. L., Griest, S., Jastreboff, P. J., Vernon, J. A., Kaelin, C., Meikle, M. B., Lyons, K. S., & Stewart, B. J. (2006). Outcomes of Clinical Trial: Tinnitus Masking versus Tinnitus Retraining Therapy. Journal of the American Academy of Audiology, 17(02), 104–132. https://doi.org/10.3766/jaaa.17.2.4
  6. Sereda, M., Xia J., El Refaie, A., Hall, D., A., & Hoare, D. J. (2018). Sound therapy (using amplification devices and/or sound generators) for tinnitus. Cochrane Database of Systematic Reviews, (12). https://doi.org/10.1002/14651858.CD013094.pub2
Benefit of proprietary neuromodulation
  1. Theodoroff, S. M., McMillan, G. P., Zaugg, T. L., Cheslock, M., Roberts, C., & Henry, J. A. (2017). Randomized controlled trial of a novel device for tinnitus sound therapy during sleep. American Journal of Audiology, 26(4), 543–554. https://doi.org/10.1044/2017_AJA-17-0022
  2. Theodoroff, S. M., McMillan, G. P., Schmidt, C. J., Dann, S. M., Hauptmann, C., Goodworth, M. C., Leibowitz, R. Q., Random, C., & Henry, J. A. (2022). Randomised controlled trial of interventions for bothersome tinnitus: DesyncraTM versus cognitive behavioural therapy. International Journal of Audiology, 61(12), 1035–1044. https://doi.org/10.1080/14992027.2021.2004325
  3. Tass, P. A., Adamchic, I., Freund, H. J., von Stackelberg, T., & Hauptmann, C. (2012). Counteracting tinnitus by acoustic coordinated reset neuromodulation. Restorative Neurology and Neuroscience, 30(2), 137–159. https://doi.org/10.3233/RNN-2012-110218
Pink noise for hyperacusis in combination with education and counseling
  1. Noreña, A. J., & Chery-Croze, S. (2007). Enriched acoustic environment rescales auditory sensitivity. Neuroreport, 18(12), 1251–1255. https://doi.org/10.1097/WNR.0b013e3282202c35
  2. Vernon, J. A. (1987). Pathophysiology of tinnitus: a special case–hyperacusis and a proposed treatment. The American Journal of Otology, 8(3), 201–202.
  3. Lindsey, H. (2014). Help for Hyperacusis: Treatments Turn Down Discomfort. The Hearing Journal, 67(8), 22–28. https://doi.org/10.1097/01.HJ.0000453391.20357.f7
Tinnitus prevalence is 10-15% of the world population / 20% need clinical intervention
  1. Jarach, C. M., Lugo, A., Scala, M., van den Brandt, P. A., Cederroth, C. R., Odone, A., Garavello, W., Schlee, W., Langguth, B., & Gallus, S. (2022). Global prevalence and incidence of tinnitus: a systematic review and meta-analysis. JAMA Neurology, 79(9), 888–900. https://doi.org/10.1001/jamaneurol.2022.2189
  2. Cima, R. F. F., Mazurek, B., Haider, H., Kikidis, D., Lapira, A., Noreña, A., & Hoare, D. J. (2019). A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO, 67(1), 10–42. https://doi.org/10.1007/s00106-019-0633-7
  3. Tunkel, D. E., Bauer, C. A., Sun, G. H., Rosenfeld, R. M., Chandrasekhar, S. S., Cunningham Jr, E. R., Archer, S. M., Blakley, B. W., Carter, J. M., Granieri, E. C., Henry, J. A., Hollingsworth, D., Khan, F. A., Mitchell, S., Monfared, A., Newman, C. W., Omole, F. S., Philips, C. D., Robinson, S. K., . . . Whamond, E. J. (2014). Clinical practice guideline: Tinnitus. Otolaryngology–Head and Neck Surgery, 151(2_suppl), S1–S40. https://doi.org/10.1177/0194599814545325 
90% of people experiencing tinnitus have hearing loss
  1. Cima, R. F. F., Mazurek, B., Haider, H., Kikidis, D., Lapira, A., Noreña, A., & Hoare, D. J. (2019). A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO, 67(1), 10–42. https://doi.org/10.1007/s00106-019-0633-7
  2. Sereda, M., Xia J., El Refaie, A., Hall, D., A., & Hoare, D. J. (2018). Sound therapy (using amplification devices and/or sound generators) for tinnitus. Cochrane Database of Systematic Reviews, (12). https://doi.org/10.1002/14651858.CD013094.pub2
  3. Mazurek, B., Böcking, B., Dobel, C., Rose, M., & Brüggemann, P. (2023). Tinnitus and Influencing Comorbidities. Laryngo-Rhino-Otologie, 102(S01), 50–58. https://doi.org/10.1055/a-1950-6149
Tinnitus is associated with hearing loss, noise exposure, stress, aging
  1. Shore, S. E., Roberts, L. E., & Langguth, B. (2016). Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment. Nature Reviews Neurology, 12(3), 150–160. https://doi.org/10.1038/nrneurol.2016.12
  2. Cima, R. F. F., Mazurek, B., Haider, H., Kikidis, D., Lapira, A., Noreña, A., & Hoare, D. J. (2019). A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO, 67(1), 10–42. https://doi.org/10.1007/s00106-019-0633-7
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